www.med.uoc.gr Department  of  Biochemistry - Division of Basic Sciences - University  of  Crete
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Kardassis Dimitris


Prokova, P., Mavridou, S., Papakosta, P. And Kardassis, D. (2005) Cracterization of a ovel transactivation domain in the Transforming Growth Factor β regulated Smad3 protein. Nucl Acids Res. 33, 3708-3721

Koutsodontis, G., Vasilaki, E., Cou, W.C., Papakosta, P. and Kardassis, D. (2005) Physical and functional interactions between members of the tumor suppressor p53 and the Sp families of transcription factors: Importance for the regulation of genes involved in cell cycle arrest and apoptosis. Biochem. J. 389, 443-455.

Koutsodontis, G. and Kardassis, D., (2004) Inhibition of p53-mediated transcriptional responses by Mithramycin A. Oncogene. 23, 9190-200.

Chou, C., Prokova, V., Shiraishi, K., Valcourt, U., Moustakas, A., Hadzopoulou-Cladaras, M., Zannis, V and Kardassis D. (2003) Smad proteins co-activate hepatocyte nuclear factor 4 by interacting with multiple domains and enhance hepatic gene transcription. Mol Biol Cell 14, 1279-1294.

Prokova V, Mosialos G, Kardassis D. (2002) Inhibition of transforming growth factor β signaling and Smad-dependent activation of transcription by the latent membrane protein 1 of Epstein Barr Virus. J Biol Chem. 277(11):9342-50

Koutsodontis G, Tentes I, Papakosta P, Moustakas A, Kardassis D. (2001) Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein.
J Biol Chem. 276, 29116-25.

Pardali, K., Kurisaki, A., Moren A., ten Dijke, P., Kardassis, D. and Moustakas, A. (2000) Role of Smad proteins and transcription factor Sp1 in p21/WAF1/Cip1 regulation by Transforming Growth Factor β. J Biol Chem. 275, 29244-56.

Kardassis, D., Pardali, K. and Zannis, V. (2000) SMAD proteins transactivate the human apoC-III promoter by interacting physically and functionally with Hepatocyte Nuclear Factor 4. J. Biol. Chem. 275, 41405-14.

Kardassis, D, Papakosta, P, Pardali, K. and Moustakas, A. (1999) c-Jun transactivates the promoter of the human p21/WAF-1 gene by acting as a superactivator of the ubiquitous transcription factor Sp1. J. Biol. Chem. 274, 29572-29581

Moustakas, A. and Kardassis, D. (1998) Activation of the human p21/WAF1/Cip1 gene promoter in hepatic cells by interactions between Sp1 and Smad family members. Proc Natl Acad Sci U S A. 95, 6733-8.


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