Publications
Prokova, P., Mavridou, S., Papakosta, P. And Kardassis, D. (2005) Cracterization
of a ovel transactivation domain in the Transforming Growth Factor β regulated
Smad3 protein. Nucl Acids Res. 33, 3708-3721
Koutsodontis, G., Vasilaki, E., Cou, W.C., Papakosta, P. and Kardassis,
D. (2005) Physical and functional interactions between members of the
tumor suppressor p53 and the Sp families of transcription factors: Importance
for the regulation of genes involved in cell cycle arrest and apoptosis.
Biochem. J. 389, 443-455.
Koutsodontis, G. and Kardassis, D., (2004) Inhibition of p53-mediated
transcriptional responses by Mithramycin A. Oncogene. 23, 9190-200.
Chou, C., Prokova, V., Shiraishi, K., Valcourt, U., Moustakas, A., Hadzopoulou-Cladaras,
M., Zannis, V and Kardassis D. (2003) Smad proteins co-activate hepatocyte
nuclear factor 4 by interacting with multiple domains and enhance hepatic
gene transcription. Mol Biol Cell 14, 1279-1294.
Prokova V, Mosialos G, Kardassis D. (2002) Inhibition of transforming
growth factor β signaling and Smad-dependent activation of transcription
by the latent membrane protein 1 of Epstein Barr Virus. J Biol Chem. 277(11):9342-50
Koutsodontis G, Tentes I, Papakosta P, Moustakas A, Kardassis D. (2001)
Sp1 plays a critical role in the transcriptional activation of the human
cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor
suppressor protein.
J Biol Chem. 276, 29116-25.
Pardali, K., Kurisaki, A., Moren A., ten Dijke, P., Kardassis, D. and
Moustakas, A. (2000) Role of Smad proteins and transcription factor Sp1
in p21/WAF1/Cip1 regulation by Transforming Growth Factor β. J Biol Chem.
275, 29244-56.
Kardassis, D., Pardali, K. and Zannis, V. (2000) SMAD proteins transactivate
the human apoC-III promoter by interacting physically and functionally
with Hepatocyte Nuclear Factor 4. J. Biol. Chem. 275, 41405-14.
Kardassis, D, Papakosta, P, Pardali, K. and Moustakas, A. (1999) c-Jun
transactivates the promoter of the human p21/WAF-1 gene by acting as a
superactivator of the ubiquitous transcription factor Sp1. J. Biol. Chem.
274, 29572-29581
Moustakas, A. and Kardassis, D. (1998) Activation of the human p21/WAF1/Cip1
gene promoter in hepatic cells by interactions between Sp1 and Smad family
members. Proc Natl Acad Sci U S A. 95, 6733-8.
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